Effects
of sodium butyrate on mineralized nodule formation, the expression of M-CSF and
OPG by osteoblasts
Tomoko Katono*,Takayuki Kawato*, ***,Natsuko Tanabe*,
***,
Naoto Suzuki**, ***,Kichibee Otsuka**, ***,Masao Maeno*, ***
Departments of Oral Health Sciences*, Biochemistry**,
Division of Functional Morphology,
Butyric acid (BA) is a major metabolic by-product of main periodontopathic bacteria
present in subgingival plaque. In the present study,
we examined the effects of BA on mineralized nodule formation, the expression of extracellular matrix protein,
macrophage colony-stimulating factor (M-CSF), and osteoprotegerin
(OPG) in normal human osteoblasts. Our results suggest that BA of low concentration stimulates
bone formation by increasing extracellular matrix protein, especially bone sialoprotein and osteopontin , whereas it suppresses osteoclast
differentiation by increasing the production of OPG and by decreasing the production of M-CSF by human osteoblasts.