Effects of sodium butyrate on mineralized nodule formation, the expression of M-CSF and OPG by osteoblasts

 

Tomoko Katono*Takayuki Kawato*, ***Natsuko Tanabe*, ***

Naoto Suzuki**, ***Kichibee Otsuka**, ***Masao Maeno*, ***

Departments of Oral Health Sciences*, Biochemistry**,

Division of Functional Morphology, Dental Research Center***,

Nihon University School of Dentistry

Butyric acid (BA) is a major metabolic by-product of main periodontopathic bacteria present in subgingival plaque. In the present study, we examined the effects of BA on mineralized nodule formation, the expression of extracellular matrix protein, macrophage colony-stimulating factor (M-CSF), and osteoprotegerin (OPG) in normal human osteoblasts. Our results suggest that BA of low concentration stimulates bone formation by increasing extracellular matrix protein, especially bone sialoprotein and osteopontin , whereas it suppresses osteoclast differentiation by increasing the production of OPG and by decreasing the production of M-CSF by human osteoblasts.