Role of cyto-differentiation factors in periodontal orthodontic
tension side by mechanical stress
Keisuke Nakano*, ***, Takehiro Watanabe*, **, Rina Muraoka*, **,
Takako Shimizu**,
Norimasa Okafuji*, Saburo Kurihara***, Kazuhiro Yamada*, **,
Toshiyuki Kawakami*, ***
Matsumoto Dental
University Institute for Oral Science***
Recently increasing number of researches
on osteoblasts differentiation factors including
Runx2 and Msx2, have been published. However, it is reported that Msx2 suppress
function of Runx2 in some studies. In the other hand, there are some reports of
function of Msx2 as a promoter of Runx2. Therefore, Runx2 and Msx2 expressions
were examined by immunohistochemistry in mouse
periodontal ligament exposed to mechanical stress. Expressions of Runx2, Msx2
and ALP became stronger in parallel with time in periodontal tension side. Our
results suggested that Runx2 promoted differentiation of osteoblasts
and Msx2 worked as an activator of Runx2 function.