Effect
of CaTiO3-aC Coating Material
by Thermal Decomposition Method on Osteoblastic Cell
Response
Hiroyuki Matsuda*, Miho
Inoue*, Andrea P. Rodriguez*, Silvia S. Borkosky*, Ryo
Tamamura*,
Masahisa Inoue**, Tohru Tagagi*, Shin Takagi***,
Masaru Akao*, Noriyuki Nagai*
Department of Oral
Pathology,
Dentistry and
Pharmaceutical Sciences,
Laboratory for Structure and Function, Faculty of Pharmaceutical Sciences, Tokushima Bunri University**
Department of Oral and
Maxillofacial Reconstructive Surgery,
HA-coated
titanium implants has excellent biocompatibility and mechanical properties.
However, the adherence of HA film formed on titanium substrate is weak, because
of the lack of chemical interaction between HA and titanium. A solution to this
problem is to form an intermediate film on titanium substrate. Because of this,
we have developed a novel biomaterial called Calcium Titanium Oxide –Amorphous Carbon
(CaTiO3-aC; patent:
2005-269868; 2005-269869). The purpose of this study was identification of
cellular proliferation and differentiation of osteogenic
cells. Osteoblastic cell line
MC3T3-E1 were cultured on CaTiO3-aC and HA coating plates. CaTiO3-aC had high cellular proliferation and differentiation compared to
HA. In conclusion, we suggested that CaTiO3-aC could be considered an important
candidate not only as an intermediate film but also as a coating material.