Effect of CaTiO3-aC Coating Material by Thermal Decomposition Method on Osteoblastic Cell Response

 

Hiroyuki Matsuda*, Miho Inoue*, Andrea P. Rodriguez*, Silvia S. Borkosky*, Ryo Tamamura*,

Masahisa Inoue**, Tohru Tagagi*, Shin Takagi***, Masaru Akao*, Noriyuki Nagai*

Department of Oral Pathology, Graduate School of Medicine,

Dentistry and Pharmaceutical Sciences, Okayama University*

Laboratory for Structure and Function, Faculty of Pharmaceutical Sciences, Tokushima Bunri University**

Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University***

 

HA-coated titanium implants has excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak, because of the lack of chemical interaction between HA and titanium. A solution to this problem is to form an intermediate film on titanium substrate. Because of this, we have developed a novel biomaterial called Calcium Titanium Oxide –Amorphous Carbon (CaTiO3-aC; patent: 2005-269868; 2005-269869). The purpose of this study was identification of cellular proliferation and differentiation of osteogenic cells. Osteoblastic cell line MC3T3-E1 were cultured on CaTiO3-aC and HA coating plates. CaTiO3-aC had high cellular proliferation and differentiation compared to HA. In conclusion, we suggested that CaTiO3-aC could be considered an important candidate not only as an intermediate film but also as a coating material.