Possibility of Drug Delivery System (DDS) for hard tissue

 

Kikuji Yamashita, Kaori Sumida, Kaori Abe,

Tatsuo Ishikawa, Akemichi Ueno**,  Seiichiro Kitamura

Department of Oral and Maxillofacial Anatomy, Institute of Health Bioscience,

University of Tokushima Graduate School

Department of Hygiene Chemistry, School of Pharmaceutical Sciences, Ohu University**

 

  Object: Whether collagen is suitable supporting materials for Drug Deriver System (DDS) for hard tissue or not, is clarified. Methods: The ability of adhesion of collagen to various molecules was analyzed. Then, the movement of collagen at the surface of calcified titanium was observed by Scanning and Transmission Electron Microscope. Results: It was clarified that collagen stuck close together to various molecules and collagen fibers for hard tissue were formed at the surface of calcified titanium. Discussion: The atelocollagen were considered to be suitable supporting materials for DDS with controlling release of drug and tissue peculiarity for hard tissues.