Possibility of Drug Delivery
System (DDS) for hard tissue
Kikuji Yamashita*, Kaori Sumida*, Kaori Abe*,
Tatsuo
Ishikawa*, Akemichi Ueno**, Seiichiro Kitamura*
Department
of Oral and Maxillofacial Anatomy, Institute of Health Bioscience,
University
of Tokushima Graduate School*
Department of Hygiene Chemistry, School of
Pharmaceutical Sciences, Ohu University**
Object: Whether collagen is suitable supporting
materials for Drug Deriver System (DDS) for hard tissue or not, is clarified.
Methods: The ability of adhesion of collagen to various molecules was analyzed.
Then, the movement of collagen at the surface of calcified titanium was
observed by Scanning and Transmission Electron Microscope. Results: It was
clarified that collagen stuck close together to various molecules and collagen
fibers for hard tissue were formed at the surface of calcified titanium.
Discussion: The atelocollagen were considered to be
suitable supporting materials for DDS with controlling release of drug and tissue
peculiarity for hard tissues.