Properties of Strontium-substituted apatite cement
Emi Fujihara*,
Kazumitsu Sekine*,
Kenichi Hamada*,Kikuji
Yamashita**,
Fumiaki
Kawano*** and Kenzo Asaoaka*
Department of Biomaterials and
Bioengineering, Institute
of Health Bioscience,
University of
Department of Oral and
Maxillofacial Anatomy, Institute
of Health Bioscience,
University of
Sintered HAP is used as bone
substitute materials because of its great mechanical properties, but exhibiting
low biodegradability. a-TCP exhibits low mechanical
property but high biodegradability. We attempted to develop biodegradable low-crystalline
HAP cement using a-TCP powders and inducing Sr into
HAP. One other effect of Sr inducing is stimulating bone formation and inhibiting bone resorption, simultaneously. Sr-substituted
HAP cement showed lower mechanical properties than non- Sr-containing
cement, but its solubility was higher. We have developed biodegradable Sr-substituted
HAP cement with high solubility.