Observation
of the biocompatibility of surface-treated Ti-15%Zr-4%Nb-4%Ta alloy
Yasuko Numata1, Hiroshi
Nakada2, Toshiro Sakae3, Taketoshi Suwa2,Yoshimitsu Okazaki4,
Kihei Kobayashi5,
John P. LeGeros6, and Racquel Z. LeGeros6
1 Nihon University Graduate School of Dentistry at
2 Department of Gnatho-Oral Prosthetic Rehabilitation,
3 Department of
Histology, Cytology, and Developmental Anatomy,
4 Institute for Human Science and Biomedical
Engineering, National Institute of Advanced Industrial Science and Technology 5Nihon
University Research Center
6 Department of
Biomaterials and Biomimetics,
The purpose of this study was to observe
the biocompatibility of surface-treated Ti15Zr4Nb4Ta embedded in rabbit tibias,
and to serially measure the bone mineral density (BMD) of newly generated bone
around Ti15Zr4Nb4Ta in order to evaluate the new bone formed around
surface-treated Ti15Zr4Nb4Ta implants. The observation periods were 4 and 8
weeks. After excising tibias, micro-CT (Rigaku) was
performed and a bone mineral quantitative phantom was taken to calculate the
BMD of the newly generated bone. Our results revealed that surface-treated
Ti15Zr4Nb4Ta formed newly generated bone in the rabbit tibia, showing good
biocompatibility. Grant-in-Aid Young Scientists (B: 19791462) from the JSPS,